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Your muscle tissue could quickly breakdown causing irreversible kidney damage (a disease called rhabdomyolysis), slip into a coma, or even die. The LD50 (median lethal dosage) of doxylamine succinate is 50-500 mg/kg, depending on the person. It's best to not take any amount within or beyond that range.

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Q: If you take 90 tablets of doxylamine succinate tablets 25 mg at one time then?
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How long does doxylamine succinate stay in your body?

The amount of time that it takes doxylamine succinate to leave your system will depend on age and health. However, the average is 6-12 hours.


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Yes and no, Syndol contains paracetamol, codeine phosphate, doxylamine succinate, and caffeine. The additional Tylenol (paracetamol) can place place you at a higher risk of renal and liver failure when taken at higher dosages on its own. Generally, Syndol contains 450mg which would be the equivalent to 1 - extra strength Tylenol (it's 500mg, but 50mg is .05mg). You should not take more than 4000mg (4g) of Tylenol in any 24 hour period. So If you take 2 Syndol tablets, you've consumed 450 + 450 = 900mg or 2 extra strength Tylenol. As with any product that contain doxylamine succinate and/or codeine, do not drive or operate heavy machinery after taking it, consume clear fluids to help prevent constipation and dehydration, and remember that codeine is a narcotic and is habit forming and should not be taken for prolong periods of time.


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