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One can safely take up to 60 mg of duloxetine a day. That said, doses of up to 120 mg have not proven to be dangerous. There is no clear answer of how dangerous doses of over 12 mg daily can be. You have taken 100 mg (six 20 mg tablets). You have technically taken an overdose, and are dangerously near the limit of dosage reactions that have been tested for.

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