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Coffin-Lowry syndrome is a rare genetic disorder characterized by craniofacial (head and facial) and skeletal abnormalities, mental retardation, short stature, and hypotonia. Characteristic facial features may include an underdeveloped uppe...

This condition is inherited in an X-linked dominant pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. The inheritance is dominant if one ...

Coffin-Lowry syndrome is caused by mutations in the RSK2 gene and is inherited as an X-linked dominant genetic trait. Males are usually more severely affected than females. ChaCha!

Coffin birth (first defined by the German term sarg geburt ) is the phrase used by coroners to explain the medical phenomenon when a pregnant woman spontaneously delivers her child after her own untimely death. The spontaneous birth happens when naturally expanding gases, built up in the abdominal and pelvic areas of a decomposing (pregnant) corpse, place sufficient pressure on the mother's uterus to force an unborn baby through the birth passageway and out the vagina. Coffin births have occurred throughout human history, with paleopathologic scientists discovering instances of coffin birth in ancient countries of what is now called the continent of Europe. However, with modern embalming techniques, the occurrence of coffin birth is very rare. On the other hand, coffin births still happen when (for example) accidental deaths and murders occur or in the unlikely situation where incorrect embalming procedures are performed. (As of the beginning of the twenty-first century, the term coffin birth has rarely appeared in medical literature for about twenty-five years due to its infrequency of occurrence.)

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Q: How was coffin lowry syndrome discovered?
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