It doesn't matter how many times you got the cootie shot on the playground; when you kiss another person, you're going mouth-to-mouth with their germs. When you kiss you swap germs by swallowing spit.
Also most importantly, when a man kisses a female partner, he passes a small amount of his cytomegalovirus to her. If the cytomegalovirus is introduced into a woman's system during pregnancy, it can damage or even potentially kill the fetus. But, if a woman kisses the same partner repeatedly, she eventually develops an immunity to his particular cytomegalovirus, decreasing the chances of infection during pregnancy.
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