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4 grams of Tylenol (APAP - its the 500 part of the hydrocodone) is the limit for the human liver. I wouldn't recommend taking more than 2 grams of Tylenol in 24 hrs. The stuff is really hard on your liver.
So taking 8 5-500 Hydros is putting you right at the 4 gram limit.
Note: I am not a doctor, I just play one on TV
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