How long do the effects of tadalafil last?

Answer 1

In May 2002, Lilly ICOS reported to the American Urological Association that clinical trial testing demonstrated that tadalafil was effective for up to 36 hours, and one year later, the FDA approved tadalafil (Cialis). One advantage Cialis has over Viagra and Levitra is its 17.5-hour half-life when compared to the four-hour half-life of sildenafil (Viagra). Thus Cialis is advertised to work for up to 36 hours, after which time there remains approximately 25 percent of the absorbed dose in the body. Personal Note: I'm on prescription morphine (slow-release tablets) for severe, chronic hip pain (due to the results of an auto accident that required 5 month's hospitalization), pending a hip replacement operation. Morphine, like many narcotics, affects libido and erectile function or quality. So my doctor recently prescribed me Cialis (tadalafil) 20 mg to counter these effects of morphine. I find that this dosage is effective for more than 36 hours in my case. Actually closer to 48 hours (2 days & nights), although the effects taper off so gradually and continually that it's difficult to state exactly how many hours. In my case, half the 20 mg tablet, followed by the other half tablet 24 hours later, allow my girlfriend/fiancee & myself an enjoyable long weekend of intimacy. I'm still adjusting the dosage & frequency for optimal results. I'm 55, 6'2", 240 lbs. YMMV = YOUR MILEAGE MAY VARY.