Can achondroplasia be passed on to offspring?
Yes. Most cases of achondroplasia are associated with a dominant
mutant form of the FGFR3 gene. Thus, if someone with achondroplasia
has children with a person without achondroplasia, 50% of the
offspring would be predicted to inherit the disorder. If two people
with achondroplasia were to have children, 50% would inherit
acondroplasia (i.e. would be heterozygous for the mutant FGFR3
allele), 25% would be normal, and 25% would inherit two copies of
the mutant FGFR3 allele, a condition which is almost certainly
lethal.