That really depends upon the kind of work that you want to do. I could type without a thumb if I wanted to (I only use it to hit the space bar, which I could do with other fingers if I wanted to). And there are lots of jobs which consist mainly or entirely of typing. But I wouldn't want to work in a shipping and receiving department without a thumb.
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Pretty hard. You can't pick pick up small things easily. You use use your thumb more than you think.