How do the glitazones work?

Answer 1

The glitazones are also called thiazolidinediones, or TZDs. The original TZD was called troglitazone (Rezulin) but has been taken off

the market because it caused serious liver damage. There are two glitazones still on the market called rosiglitazone (Avandia) and pioglitazone (Actos). They work by going right inside cells that respond to insulin (like fat cells and muscle cells), where they make those cells respond to insulin better. They make it easier for glucose to be taken inside fat cells and muscle cells, where it can be used. It often takes several weeks before the full effect of a glitazone is seen on the blood glucose. The glitazones do many other things in the body. They change some of the lipid (fat) levels in the blood. They make it harder for your body to make new bone tissue.