In most cases it has been noted that loop diuretics worsen the condition of the kidney in diabetes insip.
No, Thiazide Diuretics actually increase renal excretion of Phosphate. They inhibit the sodium-chloride symporter in the distal convoluted tubule of the kidney, leading to increased excretion of sodium, chloride, and also phosphate.
Diuretics are grouped into three main categories: thiazide diuretics, loop diuretics, and potassium-sparing diuretics. Each category works by different mechanisms to increase urine output and reduce fluid retention in the body. Thiazide diuretics are commonly used for treating high blood pressure, while loop diuretics are often used for reducing excess fluid in conditions like heart failure or kidney disease. Potassium-sparing diuretics help maintain potassium levels while promoting diuresis.
Drugs that can affect urine pH include carbonic anhydrase inhibitors (e.g. acetazolamide), which alkalinize urine, and ammonium chloride, which acidifies it. Additionally, diuretics like thiazides and loop diuretics can also affect urine pH to some extent.
Among the drugs that may interact with diuretics are:.Angiotensin-converting enzyme (ACE) inhibitors.Cholesterol-lowering drugs.Cyclosporine (Sandimmune).Potassium supplements.Lithium.Digitalis heart drugs.
The kidney
kidney failure
Tubular kidney disease-- Disease of the kidney that affect the tubules, the part of the kidney that allows certain substances to be reabsorbed back into the blood
is somking or snuffing cause of kidney stones
It depends on the channel/transporter being blocked. For example, it's well established that a type of diuretic called a loop diuretic (eg, furosemide) causes hypercalciuria, a fancy term for excess calcium in the urine. Loop diuretics work by blocking a sodium-potassium-chloride transporter in the kidney, and indirectly result in decreased calcium reabsorption from the urine. Because most kidney stones are made of calcium, the excess urinary calcium caused by loop diuretics can predispose people to kidney stones. By contrast, thiazide diuretics (eg, hydrochlorothiazide) commonly used to treat high blood pressure often cause hypocalciuria, which is decreased urinary calcium. Thiazides work by blocking a sodium-chloride transporter in the kidney, indirectly causing increased calcium reabsorption so less ends up in the urine. So thiazide is a reasonable medication to use for treating high blood pressure in patients prone to kidney stones. Thiazide and loop diuretics aren't technically "channel blockers", but I'm assuming you're using the term loosely. Perhaps I'm wrong though.
It is a very unlikely cause of kidney failure(if it is large and bilateral or affect the only existing kidney) .
yes