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What is the etiology of hyperbilirubinemia?
Hyperbilirubinemia can be caused by an increase in the production of bilirubin, decreased conjugation of bilirubin in the liver, impaired uptake of bilirubin by liver cells, or decreased excretion of bilirubin into bile. Common causes include hemolysis, liver disease, and obstruction of bile flow.
Can jaundice be prevented?
the activity of the enzyme UDP-glucuronyl transferase is low in the newborns.so UDP- glucuronic acid for conjugation is limited. this leads to high level of unconjugated bilirubin (beyond 25mg/dl) .it may cross the blood brain barrier resulting in hyperbilirubinemic toxic encephalopathy or kernicterus . prevention aspects: the drug phenobarbital is used, as it induce bilirubin metabolising enzymes in liver. in some neonates blood transfusion may be necessaryto prevent brain damage. phototherapy is continuously carried out till the serum bilirubin becomes normal. phototheraphy deals with the exposure of the jaundiced neonates to blue light as bilirubin absorbs the blue light and get converted to non toxic lumirubin and get excreted.
Can neonatal jaundice be prevented?
the activity of the enzyme UDP-glucuronyl transferase is low in the newborns.so UDP- glucuronic acid for conjugation is limited. this leads to high level of unconjugated bilirubin (beyond 25mg/dl) .it may cross the blood brain barrier resulting in hyperbilirubinemic toxic encephalopathy or kernicterus . prevention aspects: the drug phenobarbital is used, as it induce bilirubin metabolising enzymes in liver. in some neonates blood transfusion may be necessaryto prevent brain damage. phototherapy is continuously carried out till the serum bilirubin becomes normal. phototheraphy deals with the exposure of the jaundiced neonates to blue light as bilirubin absorbs the blue light and get converted to non toxic lumirubin and get excreted.
What is methyl phenobarbital?
Prodrug for Phenobarbital.
What is TBIL on a blood test?
Bilirubin is a breakdown product of heme (a part of haemoglobin in red blood cells). The liver is responsible for clearing the blood of bilirubin. It does this by the following mechanism: bilirubin is taken up into hepatocytes, conjugated (modified to make it water-soluble), and secreted into the bile, which is excreted into the intestine. Increased total bilirubin causes jaundice, and can signal a number of problems: 1. Prehepatic: Increased bilirubin production. This can be due to a number of causes, including hemolytic anemias and internal hemorrhage. 2. Hepatic: Problems with the liver, which are reflected as deficiencies in bilirubin metabolism (e.g. reduced hepatocyte uptake, impaired conjugation of bilirubin, and reduced hepatocyte secretion of bilirubin). Some examples would be cirrhosis and viral hepatitis. 3. Posthepatic: Obstruction of the bile ducts, reflected as deficiencies in bilirubin excretion. (Obstruction can be located either within the liver or in the bile duct.)
What are the pigments released by the liver in bile called?
From the glossary of medical terms the answer is: BILIRUBIN
What is the color of bilirubin?
The color of Bilirubin is orange Bilirubin is an orange color pigment in the bile
What is the meaning of phenolarbital?
The correct spelling is phenobarbital instead of phenobarbital. Phenobarbital is a sedative barbiturate drug. It is a narcotic that is typically used in the treatment of epilepsy.
How is phenobarbital classified?
Phenobarbital is classified as a barbiturate, which is a type of central nervous system depressant that is commonly used as an anticonvulsant or sedative.
Will Phenobarbital crystallize in D5?
Phenobarbital is not compatible with dextrose solutions like D5 as it can lead to crystallization. It is recommended to administer phenobarbital in a normal saline solution to prevent this issue.
End product of hemoglobin breakdown is?
bilirubin
What is another name for bile pigment?
Bilirubin.
