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There's a lot we don't currently know about lymphoid (ED3) Macrophages but it's relatively safe to assume that they do not have any major role in secreting antibodies.

Macrophages tend to engulf and enzymatically destroy foreign objects in the body, this is their major purpose, if that object is coated in antibodies they're better at destroying it but they do not produce those antibodies themselves.

The only real way that macrophages affect antibody production is that after destruction of intruder they'll present elements of the intruder to another variety of immune cell which will then go on to produce antibodies, it's also possible that they will produce interleukins or other compounds to upregulate antibody production but again: macrophages are not known to produce antibodies.

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โˆ™ 2012-02-22 10:13:07
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Q: Does lymphoid macrophages secrete antibodies into the blood?
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Lymphocytes are a type of white blood cell which secrete antibodies to destroy pathogens.


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Secondary lymphoid organs and tissues are the sites where lymphocytes are most active. The white pulp of the spleen is the common site for plasma cells to develop. Macrophages are also active in the spleen red pulp; where they engulf blood-borne antigens to be presented to T lymphocytes in the circulation.


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Macrophages are kind of blood cells which derive from the monocyte populations of the white blood cells. So all white blood cells can't be called as macrophages.


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