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It did for me! I had an allergic reaction to something, probably the lisinopril. I ended up in the ER with hives, tightness in the chest/esophagus, and difficulty swallowing. I was given an epi pen shot, Benadryl via IV, and a Rx for prednisone when I was released. They also did the bloodwork for a heart attack. I immed. went off the lisinopril. I should have gained weight this past week as the steroid is suposed to cause fluid retention. Instead, I dropped four pounds and my bloated abdomen returned to normal. I supect I was really retaining fluids with the lisinopril. I was excercising quite a bit and couldn't lose weight. The nurse in the E.R. told me that they see 2-3 people a week with allergic reactions to ACE inhibitiors, of which lisinopril is one. My internist also said that the reaction was most likely from the lisinopril. I was on it for about two years before this occurred. The effects can really creep up on you-lethargy, weight gain, foggy thinking, sore legs. I believe this is a very dangerous drug.

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15y ago
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14y ago

It can cause some minor weight loss, as HCTZ (hydrochlorothiazide) is a diuretic, meaning it makes one lose more water through urine output. If you are fluid overloaded for whatever reason, you might lose a pound or two after you start taking this medication. It is not likely that you will lose much weight, however.

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8y ago

Lisinopril and HCTZ do not cause weight gain. Since you are on blood pressure medication, weight loss is an important consideration for you. Talk with your health care provider about nutritional counseling.

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Q: Does lisinopril 25 mg HCTZ 20mg cause weight gain?
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