No it can not.
Answer:
The above answer is inaccurate; it should have said that amoxicillin will not dependably curesyphilis. Amoxicillin is often prescribed for chlamydia. For Syphilis, penicillin is most often used, and sometimes azithromycin is prescribed instead.
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Cloxacillin does not cure syphilis. Syphilis treatment requires injectible penicillin.