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Acute in this context means short-term -- it hasn't been going on long.

Exacerbation means signs and symptoms have gotten worse.

"Acute exacerbation" of a disease means the disease has been there right along, but lately it's acting up. For example, in this season in our area (spring), I see many patients with acute exacerbation of Allergies.

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Q: Does acute and exacerbation mean the same?
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