Does Namenda memantine work in preventing tolerance to adderall ADD amphetamine type drugs?

Answer 1

There has been a lot of research into the use of non-competitive NMDA antagonists to control tolerance to a variety of substances. Amphetamine tolerance is one of them, but the more promising area was in opioid tolerance, actually. There are basically two types of recreational stimulants (and stimulants being used for ADD), they are dopamine reuptake inhibitors (DARI) and dopamine releasers (DRE). These are ligands that bind to two different transporter proteins, DAT for DARIs and VMAT2 for DREs. Amphetamine is a releaser primarily (it's not a DAT ligand or has low affinity, but it does slow reuptake through a secondary mechanism). Amphetamine tolerance seems to be more responsive to NMDA type drugs, which memantine is. Memantine, however can have some nasty side effects. Ketamine, Dextromethorphan and Magnesium are all also NMDA antagonists that are effective in controlling tolerance. Dextromethorphan can be found in many OTC medicines, but use Dextromethorphan-ONLY containing products like the Robatussin Gel Caps (read the label carefully!). Standard dosage for this purpose is usually about 90 to 150mg. You may be a little sleepy so use it only at night. Ketamine is available on the blackmarket, and is extremely safe when taken without other drugs (besides your amphetamine) and you go to sleep or at least try to. Magnesium is available in health food stores, but I really can't suggest a dose, I'm not very familiar.