I absolutely do not recommend that. Alcohol can kill the positive effect that the antibiotic has on your body. Therefore the your body has to fight off the infection on its on without the help of the zithromax. A Z-pack only lasts for 5 days so just stick it out and party later.
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There is liklihood of potentiation or synergistic effect. Amphetamines and other sympathomimetic appetite suppressants should not be combined with serotonin reuptake inhibitors.