Yes, it can, although it is not a common side effect.
For my high cholesterol (I am male), I was prescribed Simvastatin (Zocor). Each time I took the prescribed dose, I had severe hot flashes. I stopped taking that statin and the hot flashes immediately stopped. Later, I was prescribed Lipitor. As with the Simvastatin, I had severe hot flashes.
I was told by my doctor that this is a known, though not very common side effect of some statins. After those experiences, I was prescribed Livalo (another statin). She said this should be much less likely to cause the hot flashes. After a month on the Livalo, I have no noticeable side effects.
If you're having night flashes taking Lipitor, I would suggest asking your doctor if another type of statin would be appropriate for your needs and be less likely to cause the hot flashes.
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