Can lidocaine be mixed with sotradecol?

Answer 1

If the lidocaine is administered as an ointment, to minimize the pain of a sotradecol injection, there should be no undue interaction difficulty. However, if the two substances are actually mixed and then placed on the skin as an ointment, or injected together in one shot, it is possible that lidocaine absorption would be enhanced, beyond what it otherwise would have been. Either two shots, or one shot and one ointment application, should be OK; one shot, or a mixed ointment, is risky.