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Can bioavailability be more than 100 percent for orally administred drugs?
Parthiban206
Basically no, due to two reasons:
- First, the drug is incompletely absorbed from the gastrointestinal tract, some of it exits the body unabsorbed along with the feces.
- Second, the absorbed amount of the drug undergoes first-pass metabolism; where the drug enters the hepatic portal system and is partly metabolized by the liver, thus, the amounts of drug reaching the systemic circulation unchanged is even less.
Moreover, its not logical for it to be more than 100%, since bioavailability by definition is the fraction of the amount of the drug administered that reaches the systemic circulation unchanged. It can't be more than 100% unless larger amounts of the drug reaches your circulation than the amount you already took orally, which is impossible.
While it cannot be more than 100% for a single dose, if the drug is administered more often than the period necessary for complete elimination from the body, total serum concentration may be higher than 100% of the single dose. Such is the case with most antibiotics for example, which are administered at intervals of 4-6-12 hours to achieve and maintain plasma concentrations higher than the single dose. (PS I am not a health professional)
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∙ 16y ago
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Can you have a list of different drugs bioavailability?
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What_drugs_have_been_taken_orally_and_recently_an_effort_should_to-blank-_to_prevent_absorption
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