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Are you asking about the Rh+ father and Rh- mother? Not a problem any more. There are drugs to prevent Rh- mom's immune system from attacking the Rh+ baby she's carrying. ALSO it was, in the past, a problem usually on second births and beyond. Some of baby's blood may have gotten into mom's blood and caused her to develop antibodies to the next baby. In the womb, baby and mom do NOT share blood.
Short answer -- No Problemo
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