Dt=DL (1+0.693Xt/t1/2) DL=Loading dose Dt=Total dose t1/2=half life t=time during which sustained release maintained.
They include:Biological half-lifeCompounds with a half-life which is shorter than 8 hours and shorter than 2 hours are good for sustained release formulations. On the other hand, drugs with a short half life yet long duration of action are not suitable for sustained release formulations.AbsorptionThe rate of release should be slower than the rate of absorption. In other words, the overall absorption rate of the drug should be consistent with the rate of release of the drug from the dosage form. Drugs which have a poor absorption are not suitable for sustained released formulations.MetabolismMetabolism can occur in the intestine. When compared with a bolus dose, sustained release increases the chances of the drugs being metabolised as they are released one by one.Margin of safety and therapeutic effectsDrugs with a narrow therapeutic window are dangerous candidates as failure of choosing the correct dosage form may lead to accidental overdose.
As nouns, dose and dosage are synonyms. Dose may also be a verb.
The recommended dosage of medication in a single dose is 0.05ml.
An adult dose is the dosage that is safe for adults to ingest. It almost always larger than a child's dosage.
quantity, dosage
No. Dosage is composed of the root dose and the suffix -age.
dosage, quantity
no
Dose can refer to the noun of a prescribed amount of medicine or the act of administering that medicine. Dosage refers solely to the first meaning.
The recommended dosage for Revolution for cats in a single dose is 6 mg per pound of body weight.
Recommended Daily Dosage