Dt=DL (1+0.693Xt/t1/2) DL=Loading dose Dt=Total dose t1/2=half life t=time during which sustained release maintained.
They include:Biological half-lifeCompounds with a half-life which is shorter than 8 hours and shorter than 2 hours are good for sustained release formulations. On the other hand, drugs with a short half life yet long duration of action are not suitable for sustained release formulations.AbsorptionThe rate of release should be slower than the rate of absorption. In other words, the overall absorption rate of the drug should be consistent with the rate of release of the drug from the dosage form. Drugs which have a poor absorption are not suitable for sustained released formulations.MetabolismMetabolism can occur in the intestine. When compared with a bolus dose, sustained release increases the chances of the drugs being metabolised as they are released one by one.Margin of safety and therapeutic effectsDrugs with a narrow therapeutic window are dangerous candidates as failure of choosing the correct dosage form may lead to accidental overdose.
As nouns, dose and dosage are synonyms. Dose may also be a verb.
An adult dose is the dosage that is safe for adults to ingest. It almost always larger than a child's dosage.
quantity, dosage
No. Dosage is composed of the root dose and the suffix -age.
dosage, quantity
no
Dose can refer to the noun of a prescribed amount of medicine or the act of administering that medicine. Dosage refers solely to the first meaning.
Recommended Daily Dosage
If you miss using the dose by less than 2 hrs, immediately apply a single drop to the affected eye and can return to the normal dosage routine post applying the dose. However, if you miss the bimatoprost dose by more than 2hrs then no need to apply the dose immediately as you can miss out on that dose. Make sure you do not overdose on the medication. Apply the next dose in the normally scheduled dosage time.
Four yellow pills per dose