Well, the short answer is "no." You wear flip flops on your feet, which are quite a distance from your eyes. Flip flops are no more toxic than regular shoes and socks, and the materials they are usually made of are not absorbed by skin, so there's little if any danger of flip flops having any effect whatsoever on your eyes.
On the other hand, it may depend on what you do with your flip flops. If you walk while wearing them, that is good: that's what they were made for. But if you wear them like sunglasses, that could be bad. Most flip flops are not transparent, and you can't see through them. They would certainly shield out the damaging effects that ultraviolet radiation can have, but if worn constantly, could have a deleterious effect on your natural eyesight. Not only that, but you might find yourself bumping into furniture and so on.
Inserting a flip flop (or anything else) into the eye is a very bad idea. You could scratch your cornea or puncture your eyeball. A burning flip flop near the eye could give you irritation from smoke, or, if it touched the eye, could permanently blind you.
Concerning your eyes, you should use flip flops with caution. Generally, that means using them as footwear.
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