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What is the genotype of two normal parents who have a child with cystic fibrosis?
Wiki User
∙ 13y ago
The genotype would have to be homozygous recessive if the child was completely effected by the disease. The "normal" paretns would have to have heterozygous recessive genotypes. This makes sense since the allele that causes sickle cell shows incomplete dominance when present with a normal allele in a pair. The "normal" parents actually would have a mixture of sickle cell shaped red blood cells combined with normal shaped ones. The carrier parents does not display symptoms of the disease since the regular red blood cells alone can fill the body's need for oxygen under normal circumstances. The only time the cArrier would notice would be under times of extreme oxygen demand, such as a sprint.
Wiki User
∙ 14y ago
Wiki User
∙ 13y agoTwo normal parents can produce a child that has cystic fibrosis if both parents are heterozygous (Cc) because cystic fibrosis is regulated by a recessive allele (c) and that is the only way a gene can have two recessive alleles that will then be active and cause cystic fibrosis. There would be a 25% of a child having cystic fibrosis with two normal, heterozygous parents.
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What are the chances of a normal person and a carrier for cystic fibrosis have a kid with cystic fibrosis?
Zero. Cystic fibrosis is an autosomal recessive disease. This means that both parents must carry a mutated gene and have a 1 in 4 (25%) chance of having a child with CF.
Why can Cystic fibrosis be inherited even if neither parent has the disease?
Cystic Fibrosis is an example of a disease inherited as an autosomal recessive genetic disorder. Both parents of a baby who has Cystic Fibrosis have one abnormal recessive gene and one normal dominant gene and are therefore, Cystic Fibrosis carriers. Carriers are said to be heterozygous because they contain one normal copy of the gene and one abnormal copy. A baby who inherits cystic fibrosis has inherited the abnormal gene from both parents and is therefore said to be homozygous recessive.
When C equals normal allele and c equals allele for cystic fibrosis Set up and complete a Punnett Square for cystic fibrosis for a couple that both have heterozygous for cystic fibrosis with no sympt?
Sure! When both parents are heterozygous carriers (Cc) for cystic fibrosis, the Punnett Square would result in a 25% chance of having a child with cystic fibrosis (cc), a 50% chance of having a child who is a carrier (Cc), and a 25% chance of having a child who is not a carrier and does not have the disease (CC).
A couple who are both carriers of the gene for cystic fibrosis have two children who have cystic fibrosis What is the probability that their next child will be phenotypically normal?
If both parents are carriers on cystic fibrosis, just because two children may have the disease it doesn't mean that say,a further 3 children in future will be "normal". Inheriting genes is like a lottery. I can say though that because cystic fibrosis is recessive, every offspring born under carriers will always have a 75% chance of being phenotypically normal.
What would a genetic counselor tell parents who had cystic fibrosis or were carries of the cystic fibrosis about the chances of their children having cystic fibrosis?
If both parents are carriers then the child has a 25% chance of having cystic fibrosis. If one parent has CF and the other the other was just a carrier then the child has a 50% chance of having CF. If one parent has CF and the other has two normal genes then there is no chance of the child having CF. If one parent is a carrier and the other has two normal genes then there is no chance of the child having CF. If both parents have CF then there is a 100% chance that the child will also have CF.
What are is the percentages of a child not having cystic fibrosis with parents who both have the trait?
If both parents are carriers of the cystic fibrosis gene, each child has a 25% chance of inheriting two copies of the gene and having cystic fibrosis, a 50% chance of being a carrier like the parents, and a 25% chance of not inheriting any copies of the gene. Therefore, the percentage of a child not having cystic fibrosis with carrier parents is 25%.
Which is a genetic disorder that gene therapy may correct?
Cystic fibrosis is a genetic disorder that gene therapy may correct by introducing a healthy copy of the CFTR gene into cells to restore normal function in affected individuals.
What is cystic fibrosis gene disorder?
Cystic fibrosis is a genetic disorder that affects the lungs and digestive system. It is caused by a mutation in the CFTR gene, which leads to the production of thick and sticky mucus that can clog the airways and prevent proper digestion. This can result in respiratory infections and difficulty breathing, as well as problems with nutrient absorption and digestion.
How gene therapy might be used to treat cytic fibrosis?
Gene therapy for cystic fibrosis involves delivering a functional copy of the CFTR gene to affected cells in order to restore normal function of the protein. This can be achieved by using viral vectors to deliver the gene into the cells and allow it to produce normal CFTR protein. By correcting the underlying genetic defect, gene therapy holds promise for treating cystic fibrosis at the molecular level.
What are some facts about cystic fibrosis?
More than 1,000 different mutations in the CFTR gene have been identified in cystic fibrosis patients. The most common mutation (observed in 70% of cystic fibrosis patients) is a three-base deletion in the DNA sequence, causing an absence of a single amino acid in the protein product. About 2,500 babies are born with cystic fibrosis in the U.S. each year. More than 10 million Americans carry the cystic fibrosis gene but don't know it.
Explain why the parents of someone with cystic fibrosis do not show any symptoms?
In order to have a child with cystic fibrosis, both parents must be carriers (assuming neither of the parents actually have CF; then obviously they will have symptoms). In CF, a carrier has no symptoms, unlike sickle cell anemia, where a carrier will have mild symptoms of the disease. A carrier of CF has only one defected 7th chromosome, and the other unaffected one makes the CFTR gene work correctly. When both are defected, the result is the CF disease, and normal CFTR genes are impossible to make, causing the person to have the disease.
Are Purple fingertips in cystic fibrosis patience normal?
Yes, the finger nails are often bluish in patients with Cystic Fibrosis. Clubbing of the fingernails is also seen in later stages of CF. My daughter had CF for 34 years before dying of Sepsis (blood infection), 115 days after a double lung transplant.
