Thyroid nodules are fluid-filled or solid lumps that form within the thyroid. A hypodense nodule is simply a less dense nodule.
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Density is a measurement of mass per unit of volume, so a hypodense area has less mass for a given volume.
Typically this means it weighs less for a particular size. The implications of this depend on the particular tissue being asked about, and by what is causing the hypodensity.
Since hypo means "less, lower, too little, etc." (as opposed to hyper, meaning "too much", more", etc.) it means less dense, or lower denseness.