The higher frequency of the HbS allele in Africa is due to historical selective pressure from malaria. People with one copy of the HbS allele have increased resistance to malaria, providing a survival advantage in regions where the disease is prevalent. In the US, where malaria is not as common, there is less selective pressure for the allele to be maintained at high frequencies.
An example of allele frequency is when in a population of 100 individuals, 60 individuals have the dominant allele (A) for a specific gene, while 40 individuals have the recessive allele (a). The frequency of the dominant allele (A) would be 0.6, and the frequency of the recessive allele (a) would be 0.4.
Migration of people from regions where sickle-cell disease is common, such as Africa, to the United States primarily contributed to the change in frequency of the sickle-cell allele in the overall U.S. population. The allele confers some protection against malaria, which is prevalent in regions where the allele is common.
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Random change in allele frequency is called genetic drift.
Minor allele frequency (MAF) is the frequency at which the less common allele appears in a particular population. Major allele frequency (MAF) is the frequency at which the more common allele appears in a particular population. They are useful measures for studying genetic variation within populations.
Allele frequency refers to the proportion of a specific allele in a population's gene pool. For example, in a population of birds, the allele frequency for the gene that determines feather color might be 0.7 for the brown allele and 0.3 for the white allele.
The allele frequency in a population determines the genotype frequency. Allele frequency refers to how often a particular version of a gene appears in a population, while genotype frequency is the proportion of individuals with a specific genetic makeup. Changes in allele frequency can lead to changes in genotype frequency within a population over time.
The frequency of an allele in a gene pool is determined by counting the number of copies of that allele in a population. This frequency can change through evolutionary processes such as genetic drift, natural selection, mutation, and gene flow. Tracking allele frequencies helps scientists study population genetics and evolutionary dynamics.
Allele frequency.
malaria. This resistance is due to the fact that the sickle cell trait confers some protection against the malaria parasite, Plasmodium falciparum, making individuals less susceptible to severe malaria infections.
The sickle cell allele can be maintained in the central African population, above the frequency of gene mutation (balancing selection), because the heterozygous sickle cell individuals have an advantage in lifespan, in this malaria stricken region, over the homozygous alternatives. Homozygous sickle-sickle individuals die early from the sickle cell disease. Homozygous nonsickle-nonsickle die early from malaria. The heterozygous sickle-nonsickle have a higher survival against malaria and therefore the sickle cell allele is balanced selected.