Probably because his family despises:* Anybody who is half-blood or muggle - or, as in the case of the Weasleys, who works in favor of them. What they call a "blood traitor".
* Anybody who is in house Griffindor.
* People who worked against Lord Voldemort.
* People who are poor.
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Ron knew of the Malfoy family through his father who frequently talked about them. It is likely he laughed because of something his father had once mentioned about the family whose reputation had been low in the years following Voldemort's downfall.
Draco is taught from childhood that muggleborns and blood traitors are much lower than him. The weasleys are considered blood traitors, so they are looked down upon.
Percy Ignatius Weasley
Ginevra "Ginny" Weasley
Molly Weasley's maiden name is Prewett. If you are talking about who potrayed her in the movies, her name is Julie Walters.
In fact, Percy Weasley is Percy Weasley's real name.
Ginevra 'Ginny' Weasley.