George left ER in 2009 to pursue a career in movies.
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George Clooney left the TV show ER in 1999
As a singer
George Clooney played the Dr. Douglas in the TV series "ER".
Yes they are friends. George Clooney guest stared on Friends for 1 episode as a cute ER doctor. Friends and ER sets were near by each other. In addition, Clooney stared in Ocean's Eleven and Ocean's Twelve with Aniston's then husband Brad Pitt. Also Aniston participated in Clooney's telethon to help Haiti.
George Clooney was born in Lexington, Kentucky.