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In the comic books, Deadpool was given Wolverine's powers via experimentation, in order to treat his brain cancer which would otherwise have been fatal to him. That's part of the reason he went insane, because his cancer was never actually cured, but it keeps reappearing and healing over and over again. In some versions I believe he also has a belt which allows him to teleport.

In the movie, he had many more powers taken from several other X-men mutants, including Cyclops's eye blasts, natural teleportation, and Wolverine-inspired swords that extend from his wrists.

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