Some words that have O as the second letter are:
Well, I only cheated a little.
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Some four letter words with second letter U and fourth letter O are:autoeurojudokudoouzo
Some five letter words with the second and fifth letter O are:bongocondofolioforgolottomottopoliorodeotorso
Five letter words with the second and fourth letter O are:boronbosomcocoacoloncolordonorhonormoronmotorrobotrotor
Lake HURONSome words that have O as the second to last letter are:actorarborardorbloombroomcolordroopgloomgroomheronfloorfurormajormayormelonmoronmotorproofrumorsalonshootspoontumorvalorvaporwhoop
vowel