Some words that have O as the second letter are:
Well, I only cheated a little.
Some four letter words with second letter U and fourth letter O are:autoeurojudokudoouzo
Some five letter words with the second and fifth letter O are:bongocondofolioforgolottomottopoliorodeotorso
Five letter words with the second and fourth letter O are:boronbosomcocoacoloncolordonorhonormoronmotorrobotrotor
Lake HURONSome words that have O as the second to last letter are:actorarborardorbloombroomcolordroopgloomgroomheronfloorfurormajormayormelonmoronmotorproofrumorsalonshootspoontumorvalorvaporwhoop
vowel
Some four letter words with second letter U and fourth letter O are:autoeurojudokudoouzo
Some five letter words with the second and fifth letter O are:bongocondofolioforgolottomottopoliorodeotorso
boardsbonnetbookiecoffeecomedy
Mohawk
Five letter words with the second and fourth letter O are:boronbosomcocoacoloncolordonorhonormoronmotorrobotrotor
Lake HURONSome words that have O as the second to last letter are:actorarborardorbloombroomcolordroopgloomgroomheronfloorfurormajormayormelonmoronmotorproofrumorsalonshootspoontumorvalorvaporwhoop
Some four-letter words with the second letter "o" include: book, food, foot, pool, look, loop, cool, and soon. These words all have the commonality of having the letter "o" as the second letter in their spelling.
Some five letter words with O and M as the second and third letter are:combocometcommacomicdomedhomerhomeymommynomadoomphromanromeorompervomitwomanwomen
vowel
Some five letter words with second letter O and fourth letter E are:bogeybowelbowercometcovencoverdowelhotellosermodelmowernoseynovelpowerrover
piezo
unto, undo, updo