It depends which game your playing, and what version of the game.
If its Pokemon Diamond, or Pearl, you need a Trainer Kit which is a software used to hack in-game sprites. This is for the Nintendo DS Only at the moment.
If your playing a ROM game on en Emulator, such as Ruby or Saphire, you can just edit the software to make yourself another Sprite.
Hope it Helped.
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pokemon overworldeditorRE i think on whack a hack
Find an online tutorial and then use any image editing program (even paint) to make them.
i personally use a program called unLZ-gba. google it for a tutorial
My reccomendation is to use YAPE. I did! MalwareRemovalBot is NOT a ROM hack program, so don't listen to the other guy!
Unity 3D :)