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If you mean while using an emulator, it depends on the emulator you are using. Check in the options for the controls.
If you are using an emulator like VBA to play Pokemon Fire Red then you do not save as you normally do. You save using the emulator controls.
you must comfigure the controls on the vba not game..as there is no diff key set
The best emulator is NO$GBA
you cannot trade on the visual boy advance emulator.