The overall best weapon is the Plasma Cutter. This is the first weapon you will acquire in the game.
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I think the 3 best weapons in Dead Space are the:Plasma CutterLine GunRipper
When the player completes Dead Space 2 on the Hard Core difficulty setting (The hardest setting) they unlock a unique weapon at the Store called the 'Hand Cannon'. This is a novelty weapon that looks like a foam hand. It doesn't require any ammunition and therefore doesn't need to be reloaded. It also does very high damage, has unlimited range and no cross hair.
The best weapon is to cut people
dead space 2 dead space day of the dead
There are a total of 12 chapters in Dead Space.