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I would personally use monsters with 2000 or higher DEF points that you can just set on the field. Also, I would include the trap card 'A Feint Plan' which will protect your set monsters for a turn so you can possibly summon a strong monster to the field. Stopping your opponent with 'Mirror Force' 'Sakuretsu Armor' and ' Magic Cylinder would be a great defensive strategy. This is arguably the best ultimate defence in Yu-Gi-Oh.

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13y ago
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Q: What is the best ultimate defence for Yu-Gi-Oh?
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