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Many trainers are stopped short by this powerful pokemon mostly because it can learn many powerful moves of different types so it's really difficult to defeat it. A couple strategies can be used to defeat Mewtwo for starters use a pokemon that has high special defense that is critical for a fight against mewtwo some good pokemon with this in mind are: Blissey, Slaking, Snorlax. Slaking i would say is the best choice because mewtwo's lowest stat is usually defense and Slaking has high attack power have it use Shadow Ball repeatedly or Hyper Beam and Mewtwo should go down easy.

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