Two strange options:
Some six letter words with the second letter U and the last letter E are:auntiebubblebucklebudgiebungleburglebustlebutanecuddlecurarecurdlecuttlefuddlefumblefutilefuturegurgleguzzlehuddlehumanehumblehurdlehurtlehustlejugglejujubejumblejunglejunkielupinelustremuddlemufflemumblemusclemutatemuzzlenuancenubilenuzzleoutagepuddlepumicepurplepursuepuzzlequichequincerubblerufflerumblerumplerustlesubduesubtlesucklesundaesupinesupplesuturetubuletumbleturtletusslevulvaeyuppie
Some six letter words with the fifth letter L are:ampuleargyleawhilebeholdbottlebubblecattlecirclecoupledangledociledwindleeasilyembalmexhalefeeblefemalefiddleheraldinsultlovelymuddleoccultrashlyresultrevoltribaldtumultunfoldvastly
Some six letter words with the second letter U are:auburnaugustauricleauroraauthorautismautumnbucketbucklebudgetbuffetbufferbulletbumblebumperbundlebunglebunkerburgleburgerbutanebutlerbutterbuttoncubismcuckoocuddlecudgelcupolacurfewcurlercursorcurtsycustomcutletcutoffcutterdugoutdulcetduplexdustereulogyeunucheurekafumblefungusfunnelfurrowfusionfutilefutureguitarguiltygulletgunnergurglegussetgutterguzzlehuddlehumblehungerhunterhustlejumblejunglejunkiekuchenlumbermuddlemumblemuttermutualnudistnuggetoustedoutfitoutrunpuddlepulleypunnetpusherputterquaintqueasyrubberruggedrusticsubtlesubmitsucklesullensupplesurreytumbleturkeyturrettussleturtlevulgar
the six letter word with e as second letter and 5th is... SECRET jestermeltedbeltedtendertendedmendeddealerheaderLentensedges
alohasclavaeclavalclimaxclinalclonalelijahfloraefloralflorasflymanflywayglobalglomalglycanllamasplagalplanarplazaspleiadplicaeplicalpluralsloganslovak
Some six letter words with the second letter U and the last letter E are:auntiebubblebucklebudgiebungleburglebustlebutanecuddlecurarecurdlecuttlefuddlefumblefutilefuturegurgleguzzlehuddlehumanehumblehurdlehurtlehustlejugglejujubejumblejunglejunkielupinelustremuddlemufflemumblemusclemutatemuzzlenuancenubilenuzzleoutagepuddlepumicepurplepursuepuzzlequichequincerubblerufflerumblerumplerustlesubduesubtlesucklesundaesupinesupplesuturetubuletumbleturtletusslevulvaeyuppie
Some six letter words with the fifth letter L are:ampuleargyleawhilebeholdbottlebubblecattlecirclecoupledangledociledwindleeasilyembalmexhalefeeblefemalefiddleheraldinsultlovelymuddleoccultrashlyresultrevoltribaldtumultunfoldvastly
Cumuli, euripi, muesli, nuclei and tumuli are 6 letter words. The 2nd letter is u and the last letter is i.
Some six letter words with the second letter U are:auburnaugustauricleauroraauthorautismautumnbucketbucklebudgetbuffetbufferbulletbumblebumperbundlebunglebunkerburgleburgerbutanebutlerbutterbuttoncubismcuckoocuddlecudgelcupolacurfewcurlercursorcurtsycustomcutletcutoffcutterdugoutdulcetduplexdustereulogyeunucheurekafumblefungusfunnelfurrowfusionfutilefutureguitarguiltygulletgunnergurglegussetgutterguzzlehuddlehumblehungerhunterhustlejumblejunglejunkiekuchenlumbermuddlemumblemuttermutualnudistnuggetoustedoutfitoutrunpuddlepulleypunnetpusherputterquaintqueasyrubberruggedrusticsubtlesubmitsucklesullensupplesurreytumbleturkeyturrettussleturtlevulgar
skunks
nearly
the six letter word with e as second letter and 5th is... SECRET jestermeltedbeltedtendertendedmendeddealerheaderLentensedges
Tactic.
happenhavinghaltedhandlehailinghearts
alohasclavaeclavalclimaxclinalclonalelijahfloraefloralflorasflymanflywayglobalglomalglycanllamasplagalplanarplazaspleiadplicaeplicalpluralsloganslovak
skinny
Some six letter words with second letter U and fourth letter K are:bucketbucklebunkercuckooduckedduckiehunkerhuskedjunkedjunkerjunketluckedlurkedmuckedmusketmuskoxpuckerpunkedquakesruckussuckersulkedsunkentuckedturkey