A Nuzlocke is a challange in Pokemon games. The rules are:
1) You can only catch the first Pokemon on each route/area. If you kill it/it runs away: tough luck.
2) If a Pokemon faints, release it.
3) Nickname all Pokemon.
You can also add more rules like one pokeball per town, no healing items in and/or outside of battle, only use a Pokemon center before a gym battle, etc....
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Pokemon Nuzlocke is a challenge you can do on any Pokemon game. The challenge is self set and it helps to make the game more challenging. For example, here are some rules people often do if they decide to take the nuzlocke challengeIf a Pokemon faints, you may no longer use it, if all your pokemon faint (Thus you white/black out) it's considered game over.You must nickname all your pokemonYou can't use the Maste BallYou can't use the Pokemon Center
To do a Nuzlocke challenge, you play the game as normal, except with two rules: 1) Catch only the first Pokemon you encounter in a route/cave. 2) If a Pokemon faints, it's dead permanently and can no longer be used. Other rules can be added at your discretion; those are just the two basic rules.
It depends on how you want to play it. The two basic rules are that you can only catch one Pokemon in an area, and if a Pokemon faints, it's dead permanently. You can also add other rules such as no healing items, no going to Pokemon Centers, and no evolving your Pokemon, depending on how hard you want the game to be.
I don't know really if it's good in emerald or not...But i tried using it in Ruby (Nuzlocke Run) and i think i would lose a pokemon to may's Combusken(all my team expect gulpin have a type-disadvantage) Here is where Gulpin shined and defeated Combusken Gulpin learns a powerfull move early (Sludge) But i suggest you try using it yourself few times to see if you like it or not.