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· Opelousas is a city in Louisiana
Oklahoma City,OKOlympia,WA
Some southern US cities that start with the letter O:Oak Ridge, TennesseeOcilla, GeorgiaOdessa, TexasOpelika, AlabamaOlive Branch, MississippiOpelousas, LouisianaOrangeburg, South CarolinaOrlando, FloridaOzark, Arkansas
U.S. state capitals that start with the letter O:Oklahoma City, OklahomaOlympia, Washington
Two counties in South Carolina begin with the letter O. Oconee and Orangeburg are counties in South Carolina.