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Six letter words starting with N:naggednailednapkinnationnaturenectarnearlyneaterneatlyneededneedleneckednegatenervesnestednestleneuternibblenicelynickelniecesnightsnimbleninetynogginnipplenobodynoodlenormalnoticenotionnovelsnovicenozzlenudgednuggetnursesnumbernurishnuzzlenylons
Some four letter words that start with U are:uglyulnaundountouponureaurgeused
sablesaltysandysaladsharesharpshanksharkskimpskillskirtslimesliceslideslopescuffscorescarfscramsmallsmilesmokespadespanksparkspeckspendspellsinceswordsheetsheersheepsceneshearsheikshakeshellshallskunkstinkstankstunkstartstampshameshiftshineswarmstormstoopstoolstovestonestolesweetsweatswearswornstumpstungstuckstackstickstockstripsteamstealsteelswingstingsnakesnackswingsmartstrumstorestorksmock
That is a trick question. You can't make a four letter word using all five vowels.
Lust