The pokemon game that has two regions is gold silver and crystal and the remakes of gold and silver heart gold, soul silver although many of the games have areas you have to take a boat to which is close to two regions but not officially a region
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There's only one region in Pokemon Sapphire, and that's the Hoenn region.
Not regions seen in other games, but you can visit some islands that are introduced in the FireRed and LeafGreen games.
KantoJohtoHoennSinnohOrreFioreAlmia
Yes you can trade Pokémon between two Pokémon Yellow games.
well heartgold and soulsilver takes place in the kanto and johto regions, so obviously the pokemon from those regions are there, though probably not in the same place as the original games. there is also hoenn region and sinnoh region pokemon in this game, but in order to get those you have to listen to a certain type of musice on the radio on a certain day in the game. for more help on where to find hoenn and sinnoh region pokemon in these games, you should really go to seribii.net