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If you don't want to waste time using other balls, yes, u should. But it is possible to nab him with another ball. Lueroi, a good YouTube video maker, caught Mewtwo with a GREAT BAll. He used his master ball on something else. If you don't want to waste your MAster ball, don't.
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In SoulSilver which Pokemon is best to use your masterball on?
You probally want to use it on mewtwo because it is level 70
Which Pokemon should you use master ball on in leaf green?
Save your MasterBall for the Ledgendary dog (Suicune, Entei or Raikou). Don't use it on Mewtwo because it is really easy to catch him with just ultra balls. Just make sure you save before you fight Mewtwo :)
When should you use the master ball in Pokemon Yellow?
Mewtwo I guess????
Should you use your masterball on Rayquaza?
no- at least not to start the battle you should try to catch it with something else you should use master ball as a last resort
What Pokemon to use to fight Zapdos in PTD power plant?
Your strongest pokemon and one the that has something to put it to sleep that's how I caught the three legendary birds and mewtwo is next. So long as you remember not to use you're masterball, it should be fine. save right before you attack though, or you may accidentally kill it.
