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If you don't want to waste time using other balls, yes, u should. But it is possible to nab him with another ball. Lueroi, a good YouTube video maker, caught Mewtwo with a GREAT BAll. He used his master ball on something else. If you don't want to waste your MAster ball, don't.

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Q: Should you use your masterball on Mewtwo?
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Related questions

Who should you use your masterball on?

I think you should use ur masterball on entei raikou or sourcune and maybey mew not mewtwo


Which ball should you use to catch Mewtwo with when it is paralyzed?

masterball


What Pokemon is the masterball used for in LeafGreen?

It isn't meant for any one pokemon. Most people use it on Mewtwo, which you probably should use it on. You can catch the legendary birds and Mewtwo without a Masterball but it can take a long time.


What poke ball you use for catch Mewtwo?

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you can use it when ever you want but i recomend using it on mewtwo


How do you catch Mewtwo in ruby?

With a Masterball


In SoulSilver which Pokemon is best to use your masterball on?

You probally want to use it on mewtwo because it is level 70


Which Pokemon in FireRed do you use the Master Ball on if you already caught Mewtwo in a Timer Ball?

Use you masterball on suicune because its impossible to catch it without a masterball it would just flee i cuaght mewtwo with a great ball but make sure you have lots of them.


What is the best ball to catch Mewtwo?

MasterBall


What Pokemon is the masterball for on FireRed?

the masterball is for any Pokemon you want, it can catch them without fail ( it will ALLWAYS work ) . you are supposed to use it for mewtwo though. :P


Which Pokemon should you use master ball on in leaf green?

Save your MasterBall for the Ledgendary dog (Suicune, Entei or Raikou). Don't use it on Mewtwo because it is really easy to catch him with just ultra balls. Just make sure you save before you fight Mewtwo :)


Catching Mewtwo on Pokemon FireRed?

you have to save your masterball no matter what and use it on mewtwo in order to catch it faster. otherwise, you are going to spend hours trying to catch it without any luck.