Sad and sorrow are two sad words that start with "s".
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Sorrowful
Leukemia is something sad that starts with "l".
qawawa quiet
Lachrymose, Lamenting, Lugubrious are three.
An eight letter word that starts with S and ends with T: satiristshortestsmallestsmarteststagnantstalwartstiffeststridentsubtract
something