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One difference is physical: XL is a white table about the size and shape of an adult aspirin. ER is the same but much smaller...diameter is less than half that of an XL. Both are coated for release of the active ingredients over time rather than just when ingested and both are generic versions of Glucotrol XL.

But see discussion page for a different viewpoint.

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Q: Is there a difference between Glipizide XL and ER?
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