13 E's, and 2 blank tiles, so 15 E's is entirely possible.
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There are 5 S's in Words With Friends. (The prior answer noted that there were 5 S's also in Scrabble. This is incorrect. In Scrabble, there are only 4 S's; Words With Friends features an additional S in its letter distribution.)
There are not any letters z in this sentence, but there are two places where you pronounce /z/: words and friends. You pronounce them as /z/ because d is a voiced sound.
There are 2 blanks In words with friends
There are about 26 words because there are 26 letters in the alphabet and any of them can be used.