I am assuming your trying to use a Xbox game with a 360 right? I would check to see if there is support but most do work in the 360. I have ran into a few that didn't work in the new one before.
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Yes, the Xbox 360 disc cleaner is actually designed to clean an Xbox 360 game disc and to clean the game system.
Game information saves on the Xbox's hard drive.
Gamestop will clean some xBox 360 game discs.
Well if u move ur xbox 360 while the game disc in inside the game may corrupt, disc damage and a affection to ur xbox.
Yes, You need the disk and you cant use your friends disk and download it to your Xbox 360 it will say you need the disk in your Xbox when you play it.