Sabrina is the toughest gym leader. The best way to fight her strong psychic pokemon is to use a pokemon than can take special hits and attack back with powerful physical attacks. Snorlax, Slobro, Hypno, Gyarados, and Lapras are all good options. Sabrina's pokemon are very fast, so it is crucial that you paralyze them. You should always have sleep powder or thunder wave on your team. If you can put her pokemon to sleep, or freeze them, you will win.
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the video will tell you everything! :] http://hk.youtube.com/watch?v=iaMyOL26f-s&feature=related
Beat the team rocket boss in silph co.
I number the blocks with top left being 1, top right being 2, bottom left 3, and bottom right 4. When you enter the gym and hit the first block, the shortest route I've found is 1,1,3.
The first gym is in pewter city.
The 5th gym is the Fuchia city gym Gym leader Koga