You can get them in drops (wizards' circle south of varrock is one place) but if you have done Rune Mysteries quest, you can craft runes for yourself. Once you have completed Rune Mysteries, grab your pickaxe and have Aubrey (he stays in the rune shop in Varrock which is behind the west bank) teleport you to the rune essence mine. Once you have as much essence as you want, time to make it into mind runes. Get a mind talisman (wizards drop them or you might be able to snag one at the Grand Exchange) because you will need it to get into the mind altar where you make your mind runes. This altar is north of Fally, very close to wildy. If you have the talisman or, even better, a mind tiara which you can put on your head so that it won't take any space in your inventory, then load your inventory with rune essence and head to the altar. Right click on the rock and follow menu to get inside. Once inside the mind altar, right click on the center rock and follow the menu for crafting runes.
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A mind tiara is a mind talisman that you wear. If you do not know what a mind talisman is, Well than a mind tiara is used for making mind runes, it helps you find the mind runecrafting place and you need a mind tiara/talisman to craft mind runes!
You click on the spellbook icon, then click on a spell to cast it. Some spells may require to to cast on some object; for example in the case of a combat spell, you must select what you want to attack. For combat spells, it is better to choose the "autocast" option (right-click on the spell), to quickly cast the spell repeatedly. Most spells require items called runes, which you must buy, find or make. Moving the mouse over a spell will show you which runes you need. The runes are used each time the spell is cast, so you need a relatively large number of runes. You can save some runes by wielding a special staff; for example, one of the most basic combat runes requires air runes and mind runes. By wielding a staff of air, you save the air runes - but you will still need to buy the mind runes.
The spell Ice Blitz requires three Water Runes, two Blood Runes, and two Death Runes.
crafting runes at alters. Use runes ess at certain alter to craft those runes. Eg water alter you crft water runes.
It depends on how many runes are needed. For example: For Wind Wave, you will need Air Runes and Blood Runes. If you have any type of staff of Air, you will need 1 slot. All other spells will need at least 2 spots, 1 Air/Element rune (depending on the staff) and the combat rune (Mind, Chaos, Death, and Blood). The only exception is Water spells, as a Tome of Frost can be used from dungeoneering, combined with an air staff and you will only need the combat rune. For Ancients, You will need space for water runes, air runes, fire runes, soul runes, blood runes, death runes, and maybe chaos runes if you are level 50-72. The ancient staff is recommended or better (best is Staff of Light) Another note would be if you only cast 1 type of spell, you only need 3-4 spaces (4 for Smoke, 3 for Shadow, Blood, and Ice). Note you may also consider law runes to Teleport, or teletabs (teleports are recommended as you will already have runes) Cosmic runes will be needed with normal spellbook if you plan to alch items. Again on normal, if you plan to bind/weaken enemies you will need nature/body runes. On Lunar or High Level Normal, you will need Astral Runes likely. At higher levels, it is NOT recommended to use a staff of an element, excluding the Tome of Frost (As this is an off hand item)