Okay, this is how you get Ho-Oh.
1)You go to GoldenRod City, defeat Team Rocket and the director will give you a clear bell.
2) Then, go to Ecruteak City and capture Suicune. Save the game before you go into the tower, just in case you kill Suicune.
3)After you catch Suicune, if you have all eight badges, defeat the Pokémon League and after that catch Entei and Raikou. (If you randomly came across them and they fled, go to your Pokédex and look up the area. If that never happened to you, and you don't know where to start, it'll be a bit more complicated. Entei and Raikou move everytime you enter a new city/town. What I did was I flew to Cherrygrove city. You know that patch of grass on Route 30? Go there and keep moving until you find a Pokémon. If it's a common one, go back into Cherrygrove and then again, go into the grass. Keep doing this until Entei or Raikou randomly appear. If you're daring, you can go duplicate your masterball that you should've received from Elm and use it on them and Ho-Oh)
4)Then, you go to Celadon. Visit the Pokémon Center and you'll find Eusine. Talk to him, and he'll tell you that he's gonna go back to Ecruteak. Stalk him there, and head for the Tin Tower. (By the way, you have to of have caught Suicune already. You have to catch all the legendary dogs before catching Ho-Oh.) There should be an elderly man there, who gives you a rainbow wing, saying "Take this to protect you".
5)Then, you have to go through the maze. (Walkthrough: http://www.YouTube.com/watch?v=REQQV0jg6dk)
Follow the maze and get to Ho-Oh. Like I said before, you can duplicate your masterballs. (Look it up on youtube or WikiAnswers.) Or you can keep throwing Ultra Balls at it. (If you're going to do that, it's best if you have a Pokémon that can use Sleep Powder.)
Have fun. :)
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Ho-oh or Lugia is the strongest Pokemon in Crystal. Tyranitar would be third strongest.
You can get lugia, ho oh, entei, suicune and raikou
the legendaries available in Crystal is Raikou, Entei and Suicune. Lugia and Ho-oh are available too.