find the file you designated to hold pokemon fire red files, each save should be numbered, right click and select delete. Done
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You open and play them in an emulator. The best GBA emulator is Visual Boy Advance. http://vba.ngemu.com/
Because if you have gameshark/action replay for GBA and save it. It get's deleting yr file
You will first need to download an emulator, a program that converts game files from a Gameboy to a PC game. Then you will need to download the actual game and follow the directions of the website.
The games are ROM files, the emulator is the virtual game system. If you have the NDS emulator, you need to acquire the ROM files you want to play as well... Normally, there is an option to open a file in the emulators menu. Select the ROM file you wish to play from the file browser and you should be able to play