I haven't played that in a while but i think it is a separate weapon, used with 4
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On the WII remote, it has the four buttons shaped like a cross. To throw a grenade, you push down the left button and aim. to throw it, you just let go. You have to throw before the red circle on your screen runs out. To throw a smoke grenade, push the right button and throw.
to use the grenade launcher you get it then press the number 3
There are many ways to kill characters on Fallout 3: Shooting Grenade Mines Missiles Mister Sandman perk (level 18 perk, useful in Rivet City when you want to dominate the town) Mini Nukes (350 per nuke) Endless ways.... use the way that works for you! Hope these options help :)
Use The Ak47 Fully modded then grenade the bottom part 3 or 5 tries would do the trick shoot top box first then grenade the bottom with the expolsives.
throw ruler